De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences.

ABSTRACT: Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable polypeptides to natural selection. Here, we systematically characterize how these de novo emerging coding sequences impact fitness in budding yeast. Disruption of emerging sequences is generally inconsequential for fitness in the laboratory and in natural populations. Overexpression of emerging sequences, however, is enriched in adaptive fitness effects compared to overexpression of established genes. We find that adaptive emerging sequences tend to encode putative transmembrane domains, and that thymine-rich intergenic regions harbor a widesp

SUBMITTER: Vakirlis N 

PROVIDER: S-EPMC7005711 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature