The Order-Disorder Continuum: Linking Predictions of Protein Structure and Disorder through Molecular Simulation.

ABSTRACT: Intrinsically disordered proteins (IDPs) and intrinsically disordered regions within proteins (IDRs) serve an increasingly expansive list of biological functions, including regulation of transcription and translation, protein phosphorylation, cellular signal transduction, as well as mechanical roles. The strong link between protein function and disorder motivates a deeper fundamental characterization of IDPs and IDRs for discovering new functions and relevant mechanisms. We review recent advances in experimental techniques that have improved identification of disordered regions in proteins. Yet, experimentally curated disorder information still does not currently scale to the level of experimentally determined structural information in folded protein databases, and disorder predictors rely

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC7005769 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature