"UniCAR"-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells.

ABSTRACT: Antigen-specific redirection of immune effector cells with chimeric antigen receptors (CARs) demonstrated high therapeutic potential for targeting cancers of different origins. Beside CAR-T cells, natural killer (NK) cells represent promising alternative effectors that can be combined with CAR technology. Unlike T cells, primary NK cells and the NK cell line NK-92 can be applied as allogeneic off-the-shelf products with a reduced risk of toxicities. We previously established a modular universal CAR (UniCAR) platform which consists of UniCAR-expressing immune cells that cannot recognize target antigens directly but are redirected by a tumour-specific target module (TM). The TM contains an antigen-binding moiety fused to a peptide epitope which is recognized by the UniCAR molecule, thereby a

SUBMITTER: Mitwasi N 

PROVIDER: S-EPMC7005792 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature