QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.

ABSTRACT: The yeast Saccharomyces cerevisiae is an attractive industrial microorganism for the production of foods and beverages as well as for various bulk and fine chemicals, such as biofuels or fragrances. Building blocks for these biosyntheses are intermediates of yeast central carbon metabolism (CCM), whose intracellular availability depends on balanced single reactions that form metabolic fluxes. Therefore, efficient product biosynthesis is influenced by the distribution of these fluxes. We recently demonstrated great variations in CCM fluxes between yeast strains of different origins. However, we have limited understanding of flux modulation and the genetic basis of flux variations. In this study, we investigated the potential of quantitative trait locus (QTL) mapping to elucidate genetic var

SUBMITTER: Eder M 

PROVIDER: S-EPMC7005809 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature