Ontology highlight
ABSTRACT:
SUBMITTER: Domingo-Rodriguez L
PROVIDER: S-EPMC7005839 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200207 1
Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemog ...[more]