Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression.

ABSTRACT: Changes in expression patterns of serum carcinoembryonic antigen at initial diagnosis (CEA^In) and disease progression (CEA^Pd) in lung cancer patients under EGFR-tyrosine kinase inhibitors (TKI) treatment may reflect different tumor progression profiles. Of the 1736 lung cancer patients identified from the cancer registry group between 2011 to 2016, we selected 517 patients with advanced stage adenocarcinoma, data on EGFR mutation status and CEA^In, among whom were 288 patients with data on CEA^Pd, eligible for inclusion in the correlation analysis of clinical characteristics and survival. Multivariable analysis revealed that CEA^In expression was associated with poor progression-free survival in patients harboring mutant EGFR. Moreover, C

SUBMITTER: Kuo YS 

PROVIDER: S-EPMC7005848 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature