Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue.

ABSTRACT: Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases. Although statin-induced muscle damage has been studied, preventive or curative therapies are yet to be reported. We exposed primary human muscle cell populations (n = 22) to a lipophilic (simvastatin) and a hydrophilic (rosuvastatin) statin and analyzed their expressome. Data and pathway analyses included GOrilla, Reactome and DAVID. We measured mevalonate intracellularly and analyzed eicosanoid profiles secreted by human muscle cells. Functional assays included proliferation and differentiation quantification. More than 1800 transcripts and 900 proteins were differentially exp

SUBMITTER: Grunwald SA 

PROVIDER: S-EPMC7005895 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature