High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis.

ABSTRACT: The intestinal microbiota is a complex community of bacteria, archaea, viruses, protists and fungi^1,2. Although the composition of bacterial constituents has been linked to immune homeostasis and infectious susceptibility^3-7, the role of non-bacterial constituents and cross-kingdom microbial interactions in these processes is poorly understood^2,8. Fungi represent a major cause of infectious morbidity and mortality in immunocompromised individuals, although the relationship of intestinal fungi (that is, the mycobiota) with fungal bloodstream infections remains undefined⁹. We integrated an optimized bioinformatics pipeline with high-resolution mycobiota sequencing and comparative genomic analyses of fecal and blood specimens from recipients of allo

SUBMITTER: Zhai B 

PROVIDER: S-EPMC7005909 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature