Molecular markers in recurrent stage I, grade 1 endometrioid endometrial cancers.

ABSTRACT:

Objectives

Stage I, grade 1 endometrial cancers have low recurrence rates and often do not receive adjuvant therapy. We compared recurrent cases to matched non-recurrent controls to evaluate for molecular markers associated with higher risk of recurrence.

Methods

A case-control study including all cases of recurrent stage I, grade 1 endometrioid endometrial cancer at one institution in a ten-year period. Cases were matched to controls by age, BMI, weight and stage. Molecular testing and immunohistochemistry were performed on archival tumor specimens: microsatellite instability (MSI-H), mismatch repair status, POLE mutational status, and next-generation sequencing.

Results

15 stage I, grade 1 endometrial cancer cases with recurrent disease and available tumor specimens

SUBMITTER: Moroney MR 

PROVIDER: S-EPMC7005911 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature