Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment.

ABSTRACT: Tumor immunosuppression may assist the immune escape of cancer cells, which promotes tumor metastasis and resistance to chemo-radiotherapy. The therapeutic strategies against tumor immunosuppression mainly focus on blocking immune checkpoint receptors, enhancing T-cell recognition and neutralizing inhibitory molecules. Although immunotherapies based on these strategies have improved the clinical outcomes, immunological nonresponse and resistance are two barriers to tumor eradication. Therefore, there is an urgent need to identify new biomarkers for patient selection and therapeutic targets for the development of combination regimen with immunotherapy. Recent studies have reported that non-protein-coding modulators exhibit important functions in post-transcriptional gene regulation, which s

SUBMITTER: Luo Y 

PROVIDER: S-EPMC7005925 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature