Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis.

ABSTRACT: Phase and polarization of coherent light are highly perturbed by interaction with microstructural changes in premalignant tissue, holding promise for label-free detection of early tumors in endoscopically accessible tissues such as the gastrointestinal tract. Flexible optical multicore fiber (MCF) bundles used in conventional diagnostic endoscopy and endomicroscopy scramble phase and polarization, restricting clinicians instead to low-contrast amplitude-only imaging. We apply a transmission matrix characterization approach to produce full-field en-face images of amplitude, quantitative phase, and resolved polarimetric properties through an MCF. We first demonstrate imaging and quantification of biologically relevant amounts of optical scattering and birefringence in tissue-mimicking

SUBMITTER: Gordon GSD 

PROVIDER: S-EPMC7006047 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature