Increased plasma concentration of cell-free DNA precedes disease recurrence in children with high-risk neuroblastoma.

ABSTRACT: BACKGROUND:Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent need to identify effective predictive biomarkers of disease recurrence. METHODS:A total of 116 patients with high-risk neuroblastoma were recruited at Beijing Children's Hospital between February 2015 and December 2017. All patients received multidisciplinary treatment, were evaluated for the therapeutic response, and then initiated on maintenance treatment. Blood samples were collected at the beginning of maintenance treatment, every 3 months thereafter, and at the time of disease recurrence. Plasma levels of cell-free DNA (cfDNA) were quantified by qPCR. Receiver operating c

SUBMITTER: Su Y 

PROVIDER: S-EPMC7006086 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature