Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis.

ABSTRACT:

Background

Our recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin C effect on ventilation time, by the control group ventilation time (which we used as a proxy for severity of disease in the patients of each trial).

Methods

We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials and reference lists of relevant publications. We included controlled trials in which the administration of vitamin C was the only difference between the study groups. We did not limit our search to randomized trials and did not require placebo control. We included all doses and all durations of vitamin C administration. One author extracted study characteri

SUBMITTER: Hemila H 

PROVIDER: S-EPMC7006137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature