Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock.

ABSTRACT:

Background

In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio may reflect differences in the response to severe vasodilation, provide novel insights into its biology, and predict clinical outcomes. The objective of these protocol prespecified and subsequent post hoc analyses was to assess the epidemiology and outcome associations of plasma ANG I and ANG II levels and their ratio in patients with catecholamine-resistant vasodilatory shock (CRVS) enrolled in the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) study.

Methods

We measured ANG I and ANG II levels at baseline, calculated their ratio, and compared these results to values from healthy volunteers (controls). We dichotomized patients accor

SUBMITTER: Bellomo R 

PROVIDER: S-EPMC7006163 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature