Targeted antenatal anti-D prophylaxis for RhD-negative pregnant women: a systematic review.

ABSTRACT:

Background

All non-sensitized Rhesus D (RhD)-negative pregnant women in Germany receive antenatal anti-D prophylaxis without knowledge of fetal RhD status. Non-invasive prenatal testing (NIPT) of cell-free fetal DNA in maternal plasma could avoid unnecessary anti-D administration. In this paper, we systematically reviewed the evidence on the benefit of NIPT for fetal RhD status in RhD-negative pregnant women.

Methods

We systematically searched several bibliographic databases, trial registries, and other sources (up to October 2019) for controlled intervention studies investigating NIPT for fetal RhD versus conventional anti-D prophylaxis. The focus was on the impact on fetal and maternal morbidity. We primarily considered direct evidence (from randomized controlled trials) o

SUBMITTER: Runkel B 

PROVIDER: S-EPMC7006196 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature