Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.

ABSTRACT:

Background

Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal carcinoma (CRC) still remains unclear.

Method

In this study, we investigated the expression and biological function of SAPCD2 in CRC. Immunohistochemistry (IHC) for SAPCD2 was performed in 410 pairs of CRC specimens and corresponding normal epithelial tissues, and in 50 adenoma tissues. Clinical pathological factors were analyzed in relation to the expression of SAPCD2. The biological functions of SAPCD2 in CRC cells and its effect on cell cycle were investigated in vitro and in vivo through gain/loss-of-function approaches.

Results

IHC showed that SAPC

SUBMITTER: Luo Y 

PROVIDER: S-EPMC7006392 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature