Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population.

ABSTRACT:

Background

The aim of this study was to explore the association between diabetic retinopathy (DR) and the variants of uncoupling proteins (UCPs) genes in a Chinese population of type 2 diabetes, in total and in patients of different glycemic status separately.

Methods

This case-control study included a total of 3107 participants from two datasets, among which 662 were DR patients (21.31%). Eighteen tag single nucleotide polymorphisms (SNPs) of UCP1, UCP2, and UCP3 were selected as genetic markers. TaqMan probes, Sequenom MassARRAY MALDI-TOF mass spectrometry platform and Affymetrix Genome-Wide Human SNP Array were used for genotyping. Online SHEsis software was used for association analysis. Bonferroni correction was used for multiple comparisons correction.

Results

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SUBMITTER: Jin P 

PROVIDER: S-EPMC7006419 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature