Multiple Pathways Involved in Palmitic Acid-Induced Toxicity: A System Biology Approach.

ABSTRACT: Inflammation is a complex biological response to injuries, metabolic disorders or infections. In the brain, astrocytes play an important role in the inflammatory processes during neurodegenerative diseases. Recent studies have shown that the increase of free saturated fatty acids such as palmitic acid produces a metabolic inflammatory response in astrocytes generally associated with damaging mechanisms such as oxidative stress, endoplasmic reticulum stress, and autophagic defects. In this aspect, the synthetic neurosteroid tibolone has shown to exert protective functions against inflammation in neuronal experimental models without the tumorigenic effects exerted by sexual hormones such as estradiol and progesterone. However, there is little information regarding the specific mechanisms of

SUBMITTER: Osorio D 

PROVIDER: S-EPMC7006434 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature