Antibiotic Use and Risk of Incident Kidney Stones in Female Nurses.

ABSTRACT: Rationale & objective:The intestinal microbiome may affect urinary stone disease by modulating the amount of oxalate absorbed from the intestine and subsequently excreted in urine. This study sought to explore the association between antibiotics, which alter the intestinal microbiota, and risk for urinary stone disease.

Study design:Prospective cohort study.

Setting & participants:5,010 women in the Nurses' Health Study (NHS) I and II who had collected 24-hour urine samples.

Exposures:Use of antibiotics during the age range of 40 to 49 (NHS II), 40 to 59 (NHS I), and 20 to 39 years (both cohorts).

Outcomes:Incident symptomatic urinary stone disease; urine composition.

Analytical approach:Cause-specific hazards reg

SUBMITTER: Ferraro PM 

PROVIDER: S-EPMC7006481 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature