Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications.

ABSTRACT: Lipid nanoemulsions are attractive drug delivery systems for lipophilic drugs. To produce nanoemulsions with droplets of very small diameter (<100 nm), we investigated thermotropic phase transitions as an alternative to the standard procedure of high-pressure homogenization. Employing shock dilution with ice-cold water during the phase inversion gives the opportunity to produce nanoemulsions without any use of potentially toxic organic solvents. The systematic investigation of the relation of the three involved components surfactant, aqueous phase and lipid phase showed that depending on the ratio of surfactant to lipid the emulsions contained particles of diameters between 16 and 175 nm with narrow polydispersity index distributions and uncharged surfaces. Nanoemulsions with particles of

SUBMITTER: Busmann EF 

PROVIDER: S-EPMC7006485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature