Bedding-generated particulate matter: implications for rodent studies.

ABSTRACT: OBJECTIVES:Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science research. Our objectives were to determine whether bedding-generated PM was present in significant concentrations in rodent cages and to identify the main factors affecting the accumulation and attenuation of bedding-generated PM inside cages. MATERIALS AND METHODS:We measured PM2.5 concentrations in cages containing common bedding materials (pine, aspen, paper, and corncob) with filter top isolator absent or present on the cages. PM2.5 concentrations were monitored with rat

SUBMITTER: Hudda N 

PROVIDER: S-EPMC7006500 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature