Development of a hydrolysis-based small-molecule hydrogen selenide (H₂Se) donor.

ABSTRACT: Selenium is essential to human physiology and has recently shown potential in the treatment of common pathophysiological conditions ranging from arsenic poisoning to cancer. Although the precise metabolic and chemical pathways of selenium incorporation into biomolecules remain somewhat unclear, many such pathways proceed through hydrogen selenide (H₂Se/HSe^-) formation. Despite this importance, well-characterized chemistry that enables H₂Se release under controlled conditions remains lacking. Motivated by this need, we report here the development of a hydrolysis-based H₂Se donor (TDN1042). Utilizing ³¹P and ⁷⁷Se NMR experiments, we demonstrate the pH dependence of H₂Se release and characterize observed reaction int

SUBMITTER: Newton TD 

PROVIDER: S-EPMC7006510 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature