Proline-promoted dehydroxylation of α-ketols.

ABSTRACT: A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.

SUBMITTER: Mostinski Y 

PROVIDER: S-EPMC7006627 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature