Persistent Proarrhythmic Neural Remodeling Despite Recovery From Premature Ventricular Contraction-Induced Cardiomyopathy.

ABSTRACT:

Background

The presence and significance of neural remodeling in premature ventricular contraction-induced cardiomyopathy (PVC-CM) remain unknown.

Objectives

This study aimed to characterize cardiac sympathovagal balance and proarrhythmia in a canine model of PVC-CM.

Methods

In 12 canines, the investigators implanted epicardial pacemakers and radiotelemetry units to record cardiac rhythm and nerve activity (NA) from the left stellate ganglion (SNA), left cardiac vagus (VNA), and arterial blood pressure. Bigeminal PVCs (200 ms coupling) were applied for 12 weeks to induce PVC-CM in 7 animals then disabled for 4 weeks to allow complete recovery of left ventricular ejection fraction (LVEF), versus 5 sham controls.

Results

After 12 weeks of PVCs, LVEF (p = 0.006) a

SUBMITTER: Tan AY 

PROVIDER: S-EPMC7006705 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature