TIM-3 genetic variants and risk of Behcet disease in the Iranian population.

ABSTRACT:

Background

Behçet disease is a prototypical systemic autoimmune disease, caused by a complex interplay between environmental and genetic factors. The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behçet disease.

Objective

The aim of this study was to test the potential association between TIM-3 gene polymorphisms and Behçet disease.

Methods

Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls. Typing of the polymorphisms was performed using multiplex PCR amplification.

Results

There were no signifi

SUBMITTER: Ataei M 

PROVIDER: S-EPMC7007023 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature