Ambient Particulate Matter Size Distributions Drive Regional and Global Variability in Particle Deposition in the Respiratory Tract.

ABSTRACT: Human exposure to airborne particulate matter (PM) increases the risk of negative health outcomes; however, substantial uncertainty remains in quantifying these exposure-response relationships. In particular, relating increased risk of mortality to exposure to PM with diameters smaller than 2.5 μm (PM2.5) neglects variability in the underlying size distribution of PM2.5 exposure and size-resolved deposition in human airways. In this study, we combine a size-resolved respiratory particle-deposition model with a global size-resolved aerosol model to estimate the variability in particle deposition along the respiratory tract due to variability in ambient PM size distributions. We find that the ratio of deposited PM mass in the tracheobronchial and alveolar regions per unit ambient PM2.5 expos

SUBMITTER: Kodros JK 

PROVIDER: S-EPMC7007101 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature