Radiofluorinated GPC3-Binding Peptides for PET Imaging of Hepatocellular Carcinoma.

ABSTRACT:

Purpose

Hepatocellular carcinoma (HCC) remains one of the most challenging diseases worldwide. Glypican-3 (GPC-3) is a cell surface proteoglycan that is overexpressed on the membrane of HCC cells. The purpose of this study was to develop a target-specific radiofluorinated peptide for positron emission tomography (PET) imaging of GPC3 expression in hepatocellular carcinoma.

Procedures

New GPC3-binding peptides (GP2076 and GP2633) were radiolabeled with F-18 using Al[¹⁸F]F labeling approach, and the resulting PET probes were subsequently subject to biological evaluations. A highly hydrophilic linker was incorporated into GP2633 with an aim of reducing the probe uptake in liver and increasing tumor-to-liver (T/L) contrast. Both GP2076 and GP2633 were radiolabeled usi

SUBMITTER: Li Y 

PROVIDER: S-EPMC7007182 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature