Toxicokinetic-Toxicodynamic Modeling of the Effects of Pesticides on Growth of Rattus norvegicus.

ABSTRACT: Ecological risk assessment is carried out for chemicals such as pesticides before they are released into the environment. Such risk assessment currently relies on summary statistics gathered in standardized laboratory studies. However, these statistics extract only limited information and depend on duration of exposure. Their extrapolation to realistic ecological scenarios is inherently limited. Mechanistic effect models simulate the processes underlying toxicity and so have the potential to overcome these issues. Toxicokinetic-toxicodynamic (TK-TD) models operate at the individual level, predicting the internal concentration of a chemical over time and the stress it places on an organism. TK-TD models are particularly suited to addressing the difference in exposure patterns between labora

SUBMITTER: Martin T 

PROVIDER: S-EPMC7007285 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature