Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib.

ABSTRACT: Gastric cancer (GC) remains the third leading cause of cancer-related death despite several improvements in targeted therapy. There is therefore an urgent need to investigate new treatment strategies, including the identification of novel biomarkers for patient stratification. In this study, we evaluated the effect of FDA-approved kinase inhibitors on GC. Through a combination of cell growth, migration and invasion assays, we identified dasatinib as an efficient inhibitor of GC proliferation. Mass-spectrometry-based selectivity profiling and subsequent knockdown experiments identified members of the SRC family of kinases including SRC, FRK, LYN and YES, as well as other kinases such as DDR1, ABL2, SIK2, RIPK2, EPHA2, and EPH

SUBMITTER: Montenegro RC 

PROVIDER: S-EPMC7007292 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature