FOXA1 Protein Expression in ER⁺ and ER^- Breast Cancer in Relation to Parity and Breastfeeding in Black and White Women.

ABSTRACT:

Background

Forkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor-negative (ER^-) breast cancer. We examined FOXA1 in breast tumor and adjacent normal tissue in relation to reproductive factors, particularly higher parity and no breastfeeding, that are associated with ER^- tumors.

Methods

We performed IHC for FOXA1 in breast tumors (n = 1,329) and adjacent normal tissues (n = 298) in the Women's Circle of Health Study (949 Blacks and 380 Whites). Protein expression levels were summarized by histology (H) scores. Generalized linear models were used to assess FOXA1 protein expression in relation to reproductive factors by ER status.

Results

ER

SUBMITTER: Cheng TD 

PROVIDER: S-EPMC7007352 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature