Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q.

ABSTRACT:

Background

Lung cancer kills more people than any other cancer in the United States. In addition to environmental factors, lung cancer has genetic risk factors as well, though the genetic etiology is still not well understood. We have performed whole exome sequencing on 262 individuals from 28 extended families with a family history of lung cancer.

Methods

Parametric genetic linkage analysis was performed on these samples using two distinct analyses-the lung cancer only (LCO) analysis, where only patients with lung cancer were coded as affected, and the all aggregated cancers (AAC) analysis, where other cancers seen in the pedigree were coded as affected.

Results

The AAC analysis yielded a genome-wide significant result at rs61943670 in POLR3B at 12q23.3. PO

SUBMITTER: Musolf AM 

PROVIDER: S-EPMC7007362 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature