Prevalence of Inherited Mutations in Breast Cancer Predisposition Genes among Women in Uganda and Cameroon.

ABSTRACT:

Background

Sub-Saharan Africa (SSA) has a high proportion of premenopausal hormone receptor negative breast cancer. Previous studies reported a strikingly high prevalence of germline mutations in BRCA1 and BRCA2 among Nigerian patients with breast cancer. It is unknown if this exists in other SSA countries.

Methods

Breast cancer cases, unselected for age at diagnosis and family history, were recruited from tertiary hospitals in Kampala, Uganda and Yaoundé, Cameroon. Controls were women without breast cancer recruited from the same hospitals and age-matched to cases. A multigene sequencing panel was used to test for germline mutations.

Results

There were 196 cases and 185 controls with a mean age of 46.2 and 46.6 years for cases and controls, respectively

SUBMITTER: Adedokun B 

PROVIDER: S-EPMC7007381 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature