[Expression of TRIM59 in Non-small Cell Lung Cancer and Its Correlation with Prognosis].

ABSTRACT: BACKGROUND:TRIM proteins are important members of E3 ubiquitin ligases, and many studies have confirmed that TRIM family members play an important role in the development of various tumors. We found that TRIM59 expression level in non-small cell lung cancer (NSCLC) was significantly increased through second-generation sequencing. The purpose of this study was to investigate the expression of TRIM59 in NSCLC and its relationship with the clinicopathological parameters as well as the prognosis of patients. METHODS:The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were excavated to analyze the expression of TRIM59 mRNA in NSCLC and its relationship with the prognosis of patients; The expression of TRIM59 protein in 90 tumor tissues and adjacent tissues was detected by

SUBMITTER: Tian H 

PROVIDER: S-EPMC7007392 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature