Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

ABSTRACT:

Background

Intravenous salbutamol is used to treat children with refractory status asthmaticus, however insufficient pharmacokinetic data are available to guide initial and subsequent dosing recommendations for its intravenous use. The pharmacologic activity of salbutamol resides predominantly in the (R)-enantiomer, with little or no activity and even concerns of adverse reactions attributed to the (S)-enantiomer.

Objective

Our aim was to develop a population pharmacokinetic model to characterize the pharmacokinetic profile for intravenous salbutamol in children with status asthmaticus admitted to the pediatric intensive care unit (PICU), and to use this model to study the effect of different dosing schemes with and without a loading dose.

Methods

From 19 children (me

SUBMITTER: Vet NJ 

PROVIDER: S-EPMC7007440 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature