Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury.

ABSTRACT: BACKGROUND:Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) results in a 3-5-fold increase in the risk of hospital mortality compared to sepsis alone. The development of therapies to reverse S-AKI could therefore significantly affect sepsis outcomes. However, the translation of therapies from preclinical studies into humans requires model systems that recapitulate clinical scenarios and the development of renal fibrosis indicative of the transition from acute to chronic kidney disease. RESULTS:Here we characterized a murine model of S-AKI induced by abdominal sepsis developing into a chronic phenotype. We applied a small molecule histone

SUBMITTER: Wen X 

PROVIDER: S-EPMC7007462 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature