Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.

ABSTRACT: Environmental contexts that are reliably associated with the use of pharmacologically active substances are hypothesized to contribute to substance use disorders. In this review, we provide an updated summary of parallel preclinical and human studies that support this hypothesis. Research conducted in rats shows that environmental contexts that are reliably paired with drug use can renew extinguished drug-seeking behavior and amplify responding elicited by discrete, drug-predictive cues. Akin to drug-associated contexts, interoceptive drug stimuli produced by the psychopharmacological effects of drugs can also influence learning and memory processes that play a role in substance use disorders. Findings from human laboratory studies show that drug-associated contexts, including social stimu

SUBMITTER: LeCocq MR 

PROVIDER: S-EPMC7007469 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature