Action-Outcome Expectancies Require Orbitofrontal Neurotrophin Systems in Naive and Cocaine-Exposed Mice.

ABSTRACT: Cocaine use during adolescence decreases the likelihood that individuals will seek treatment for recurrent drug use. In rodents, developmental cocaine exposure weakens action-consequence decision-making, causing a deferral to familiar, habit-like behavioral response strategies. Here, we aimed to improve action-outcome decision-making. We found that acute pharmacological stimulation of the tyrosine/tropomyosin receptor kinase B (trkB) via 7,8-dihydroxyflavone (7,8-DHF) or 3,4-methylenedioxymethamphetamine (MDMA) blocked cocaine-induced habit biases by strengthening memory for action-outcome associations. We believe that MDMA acts by stimulating neurotrophin/trkB systems in the orbitofrontal cortex (OFC), a region involved in prospectively evaluating the consequences of one's action, because

SUBMITTER: Pitts EG 

PROVIDER: S-EPMC7007486 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature