<i>Plasmodium falciparum</i> evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor.

ABSTRACT: The surface protein Pfs47 allows Plasmodium falciparum parasites to survive and be transmitted by making them "undetectable" to the mosquito immune system. P. falciparum parasites express Pfs47 haplotypes compatible with their sympatric vectors, while those with incompatible haplotypes are eliminated by the mosquito. We proposed that Pfs47 serves as a "key" that mediates immune evasion by interacting with a mosquito receptor "the lock," which differs in evolutionarily divergent anopheline mosquitoes. Recombinant Pfs47 (rPfs47) was used to identify the mosquito Pfs47 receptor protein (P47Rec) using far-Western analysis. rPfs47 bound to a single 31-kDa band and the identity of this protein was determined by mass spectrometry. The mosquito P47Rec has two natterin-like domains an

SUBMITTER: Molina-Cruz A 

PROVIDER: S-EPMC7007573 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature