Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes.

ABSTRACT: Multiple ophthalmic pathologies, such as retinal detachment and diabetic retinopathy, require the removal and replacement of the vitreous humor. Clinical tamponades such as silicone oil and fluorinated gases are utilized but limited due to complications and toxicity. Therefore, there is a need for biocompatible, stable, vitreous humor substitutes. In this study, enzymatically crosslinked silk-hyaluronic acid (HA) hydrogels formed using horseradish peroxidase and H₂O₂ were characterized for use as vitreous humor substitutes. The composite network structure was characterized with dynamic light scattering. In addition, the rheological, optical, and swelling properties of hydrogels with varying silk to HA ratios and crosslinking densities controlled via H₂O

SUBMITTER: Raia NR 

PROVIDER: S-EPMC7007602 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature