Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.

ABSTRACT:

Rationale

Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between loss-of-function (LOF) variants in TTN and early-onset AF.

Objective

We sought to determine the contribution of rare and common genetic variation to AF risk in the general population.

Methods

The UK Biobank is a population-based study of 500 000 individuals including a subset with genome-wide genotyping and exome sequencing. In this case-control study, we included AF cases and controls of genetically determined white-European ancestry; analyses were performed using a logistic mixed-effects model adjusting for age, sex, the first 4 principal components of ancestry, empirical relationships, and case-control imb

SUBMITTER: Choi SH 

PROVIDER: S-EPMC7007701 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature