Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction.

ABSTRACT:

Rationale

Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the contribution of different cell types within this complex disease for developing new treatment options. Previous studies could prove a fundamental role of FTO (fat mass and obesity-associated protein) within obesity; however, its functional role within different cell types is less understood.

Objectives

We identify endothelial FTO as a previously unknown central regulator of both obesity-induced metabolic and vascular alterations.

Methods and results

We generated endothelial Fto-deficient mice and analyzed the impact of obesity on those mice. While the loss of endothelial FTO did not influence the development of obesity and dyslip

SUBMITTER: Kruger N 

PROVIDER: S-EPMC7007767 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature