Preparation of β²-Homologous Amino Acids Bearing Polar Side Chains via a Collective Synthesis Strategy.

ABSTRACT: β-Homologous amino acids (βhAAs) are a valuable class of building blocks for novel analogues of bioactive peptides. Thus, practical methods to synthesize enantiopure βhAAs are desirable. We report the application of a collective synthesis strategy to prepare protected β²-homologous amino acids with polar side chains. In this approach, a core structure is constructed via proline-catalyzed Mannich reaction and subsequently derivatized to furnish more than one protected β²-homologous amino acid with a proteinogenic side chain.

SUBMITTER: Liu S 

PROVIDER: S-EPMC7007826 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature