In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation.

ABSTRACT:

Purpose

The cone-beam computed tomography (CBCT)-guided small animal radiation research platform (SARRP) has provided unique opportunities to test radiobiologic hypotheses. However, CBCT is less adept to localize soft tissue targets growing in a low imaging contrast environment. Three-dimensional bioluminescence tomography (BLT) provides strong image contrast and thus offers an attractive solution. We introduced a novel and efficient BLT-guided conformal radiation therapy and demonstrated it in an orthotopic glioblastoma (GBM) model.

Methods and materials

A multispectral BLT system was integrated with SARRP for radiation therapy (RT) guidance. GBM growth curve was first established by contrast CBCT/magnetic resonance imaging (MRI) to derive equivalent sphere as approximated

SUBMITTER: Deng Z 

PROVIDER: S-EPMC7007925 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature