Metabolomics of the Protective Effect of <i>Ampelopsis grossedentata</i> and Its Major Active Compound Dihydromyricetin on the Liver of High-Fat Diet Hamster.

ABSTRACT: The flavonoid dihydromyricetin (DMY) is the main component of Ampelopsis grossedentata (Hand-Mazz) W. T. Wang (AG), a daily beverage and folk medicine used in Southern China to treat jaundice hepatitis, cold fever, and sore throat. Recently, DMY and AG were shown to have a beneficial effect on lipid metabolism disorder. However, the mechanisms of how DMY and AG protect the liver during lipid metabolism disorder remain unclear. In this study, we first analyzed the chemical compounds of AG by HPLC-DAD-ESI-IT-TOF-MS ⁿ . Of the 31 compounds detected, 29 were identified based on previous results. Then, the effects of DMY and AG on high-fat diet hamster livers were studied and the metabolite levels and metabolic pathway activity of the liver were explored by ¹

SUBMITTER: Fan L 

PROVIDER: S-EPMC7007936 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature