N-Acetyl-cysteine and Mechanisms Involved in Resolution of Chronic Wound Biofilm.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC7007959 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
<i>N</i>-Acetyl-cysteine and Mechanisms Involved in Resolution of Chronic Wound Biofilm.
Li Xin X Kim Jane J Wu Jiabin J Ahamed Alaa' I AI Wang Yinsheng Y Martins-Green Manuela M
Journal of diabetes research 20200127
Chronic wounds are a major global health problem with the presence of biofilm significantly contributing to wound chronicity. Current treatments are ineffective in resolving biofilm and simultaneously killing the bacteria; therefore, effective biofilm-resolving drugs are needed. We have previously shown that, together with <i>α</i>-tocopherol, <i>N</i>-acetyl-cysteine (NAC) significantly improves the healing of biofilm-containing chronic wounds, in a diabetic mouse model we developed, by causing ...[more]
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