Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure?

ABSTRACT:

Background

Cardiorespiratory fitness (CRF) is closely linked to health status and clinical outcomes in heart failure (HF) patients. We aimed to test whether biomarkers can reflect CRF and its change over time.

Methods

This post hoc analysis used data from ambulatory cohorts of heart failure with reduced ejection fraction (HFrEF) (IRONOUT) and heart failure with preserved ejection fraction (HFpEF) (RELAX). Cardiopulmonary exercise testing, 6-minute walk distance (6MWD), and serum biomarkers were measured at baseline and 16- or 24-week follow-up (for IRONOUT and RELAX respectively). Biomarkers included N-terminal pro-B-type natriuretic peptide (NT-proBNP), soluble ST2, growth differentiation factor-15, and Galectin-3.

Results

Analysis included 225 patients with HFrEF an

SUBMITTER: Fudim M 

PROVIDER: S-EPMC7008085 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature