Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer.

ABSTRACT: BACKGROUND:Accumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of serum basophil count level. METHODS:Between December 2007 and September 2013, 1029 patients diagnosed with stage I-III CRC in Fudan University Shanghai Cancer Center meeting the essential criteria were identified. The Kaplan-Meier method was used to construct the survival curves. Several Cox proportional hazard models were constructed to assess the prognostic factors. A simple predictor (CB classifier) was generated by combining serum basophil count and serum carcinoembryonic antigen (CEA) level which had long been accepted as the most important and reliable prognostic factor

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7008108 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature