Circulating β cell-specific CD8⁺ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes.

ABSTRACT: In type 1 diabetes (T1D), autoreactive cytotoxic CD8⁺ T cells are implicated in the destruction of insulin-producing β cells. The HLA-B*3906 and HLA-A*2402 class I genes confer increased risk and promote early disease onset, suggesting that CD8⁺ T cells that recognize peptides presented by these class I molecules on pancreatic β cells play a pivotal role in the autoimmune response. We examined the frequency and phenotype of circulating preproinsulin (PPI)-specific and insulin B (InsB)-specific CD8⁺ T cells in HLA-B*3906⁺ children newly diagnosed with T1D and in high-risk HLA-A*2402⁺ children before the appearance of disease-specific autoantibodies and before diagnosis of T1D. Antigen-specific CD8⁺ T cells were detected using

SUBMITTER: Yeo L 

PROVIDER: S-EPMC7008222 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature