Aspirin and Risk of Dementia in Patients with Late-Onset Depression: A Population-Based Cohort Study.

ABSTRACT:

Background

Late onset depression (LOD) often occurs in the context of vascular disease and may be associated with risk of dementia. Aspirin is widely used to reduce the risk of cardiovascular disease and stroke. However, its role in patients with LOD and risk of dementia remains inconclusive. Materials and Methods. A population-based study was conducted using data from National Health Insurance of Taiwan during 1996-2009. Patients fulfil diagnostic criteria for LOD with or without subsequent dementia (incident dementia) and among whom users of aspirin (75 mg daily for at least 6 months) were identified. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to se

SUBMITTER: Yang YH 

PROVIDER: S-EPMC7008294 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature