Environmental Predictors of Schistosomiasis Persistent Hotspots following Mass Treatment with Praziquantel.

ABSTRACT: Schistosomiasis control programs rely heavily on mass drug administration (MDA) campaigns with praziquantel for preventative chemotherapy. Areas where the prevalence and/or intensity of schistosomiasis infection remains high even after several rounds of treatment, termed "persistent hotspots" (PHSs), have been identified in trials of MDA effectiveness conducted by the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) in Kenya, Mozambique, Tanzania, and Côte d'Ivoire. In this analysis, we apply a previously developed set of criteria to classify the PHS status of 531 study villages from five SCORE trials. We then fit logistic regression models to data from SCORE and publically available georeferenced datasets to evaluate the influence of local environmental and popul

SUBMITTER: Walker JW 

PROVIDER: S-EPMC7008331 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature